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Chapter 2: What Is Migraine?

Migraine is a chronic neurological condition characterized by intense headaches, often accompanied by additional symptoms such as nausea, sensitivity to light and sound, and sometimes even visual disturbances. It is a common phenomenon that affects millions of people worldwide, although the exact cause is still not fully understood.

What Causes Migraine?

Research indicates that migraine is linked to changes in brain activity and imbalances in chemicals such as serotonin, which influence the function of blood vessels in the brain. An attack is thought to begin following an unclear trigger that activates the brain’s outer layers, particularly the dura – the thick, outermost layer of the meninges. This activation causes the release of various neurotransmitters, one of the most significant being CGRP.

How Does Pain Develop?

CGRP and other substances initiate a chain reaction that leads to several processes:

  • Activation of mast cells in the brain, which release chemicals that promote an inflammatory response.

  • Dilation of blood vessels, which not only causes headache but also increases vascular permeability.

  • Stimulation of the trigeminal nerve, which contributes to severe pain on one side of the head and face.

Common Approaches to Migraine Management

Studies show that there are various approaches aimed at reducing the frequency and intensity of migraine episodes. These include medications designed to block CGRP, as well as recommendations for lifestyle adjustments and avoidance of known triggers.

For more information about non-invasive approaches to managing migraine and ways to support reduced frequency of attacks – continue exploring our site.

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Roy Ramot

A specialist physiotherapist with over 35 years of clinical experience. Holds a Bachelor's degree in Physiotherapy from Ben-Gurion University and a Master's degree in Anatomy and Anthropology from Tel Aviv University. Roi specializes in developing orthopedic and neurological rehabilitation programs and has previously lectured in anatomy and physiology at Tel Aviv University. In addition, he volunteers with children and IDF wounded soldiers, and is passionate about providing natural and effective therapeutic solutions for everyone.

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